GENERATION OF NOVEL IN VITRO FLEXIBLE KIDNEY ORGANOID MODEL TO INVESTIGATE THE ROLE OF EXTRACELLULAR VESICLES IN INDUCTION OF NEPHROGENESIS

Abstract Background During kidney organogenesis, metanephric mesenchyme (MM) and ureteric bud (UB) interact reciprocally to form nephrons.Signaling stimuli involved in these interactions include Wnts, growth factors and nano/micro particles.How UB and MM are interacting is not completely understood.Our study investigated the signaling and communica

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